Heterogeneous Catalysts for the One-Pot Synthesis of Chemicals and Fine Chemicals

[EN] It is apparent that intensi¿cation in chemical and most
\nspeci¿cally in catalytic processes is of growing in interest
\namong researchers. This is not only because of the potential
\neconomical impact if translated into industrial application,
\nTable 24. One-Pot r,r-Dialkylation of Nitriles using Metal/HTsa
\naReaction conditions: Method A: (i) nitrile (1 mmol) carbonyl compounds (1 mmol), Pd/HT (0.1 g; Pd 0.01 mmol), toluene (3 mL), 2 h, 80 °C,
\nAr. After completion of the aldol reaction, the reaction mixture was further treated at 60 °C for 1 h under H2 (1 atm). (ii) Ole¿n (1.5 mmol), 5 h,
\n70 °C, Ar. Method B: (i) nitrile (1 mmol), alcohol (2 mL), Ru/HT (0.15 g; 0.0075…