Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression
University of Wisconsin–Madison · Tufts University · +1 more institution
Abstract
Although depressed mood is a normal occurrence in response to adversity in all individuals, what distinguishes those who are vulnerable to major depressive disorder (MDD) is their inability to effectively regulate negative mood when it arises. Investigating the neural underpinnings of adaptive emotion regulation and the extent to which such processes are compromised in MDD may be helpful in understanding the pathophysiology of depression. We report results from a functional magnetic resonance imaging study demonstrating left-lateralized activation in the prefrontal cortex (PFC) when downregulating negative affect in nondepressed individuals, whereas depressed individuals showed bilateral PFC activation.…
Citation impact
- FWCI
- 21.79
- Percentile
- 100%
- References
- 58
Authors
5- TJTom JohnstoneCorresponding
University of Wisconsin–Madison
- CMCarien M. van Reekum
University of Wisconsin–Madison
- HLHeather L. Urry
Tufts University, University of Wisconsin–Madison, Imaging, Brain, and Neuropsychiatry
- NHNed H. Kalin
University of Wisconsin–Madison
- RJRichard J. Davidson
University of Wisconsin–Madison
Topics & keywords
- Ventromedial prefrontal cortex
- Psychology
- Amygdala
- Functional magnetic resonance imaging
- Prefrontal cortex
- Neuroscience
- Ventrolateral prefrontal cortex
- Major depressive disorder