articlePLoS ONESep 16, 2013GOLD OA

SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis

RARaúl Aguirre‐GamboaHGHugo Gómez-RuedaEMEmmanuel Martínez-LedesmaAMAntonio Martínez‐TorteyaRCRafael Chacolla-Huaringa

Tecnológico de Monterrey

PubMed
Indexed incrossrefdoajpubmed

Abstract

Validation of multi-gene biomarkers for clinical outcomes is one of the most important issues for cancer prognosis. An important source of information for virtual validation is the high number of available cancer datasets. Nevertheless, assessing the prognostic performance of a gene expression signature along datasets is a difficult task for Biologists and Physicians and also time-consuming for Statisticians and Bioinformaticians. Therefore, to facilitate performance comparisons and validations of survival biomarkers for cancer outcomes, we developed SurvExpress, a cancer-wide gene expression database with clinical outcomes and a web-based tool that provides survival analysis and risk assessment of cancer…

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Topics
Keywords
  • Biomarker
  • JavaScript
  • Computer science
  • Biomarker discovery
  • Database
  • Web application
  • Cancer
  • Bioinformatics
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