reviewOxidative Medicine and Cellular LongevityJan 1, 2013HYBRID OA

Cadmium and Its Neurotoxic Effects

BWBo WangYDYanli Du

Inner Mongolia University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Cadmium (Cd) is a heavy metal that has received considerable concern environmentally and occupationally. Cd has a long biological half-life mainly due to its low rate of excretion from the body. Thus, prolonged exposure to Cd will cause toxic effect due to its accumulation over time in a variety of tissues, including kidneys, liver, central nervous system (CNS), and peripheral neuronal systems. Cd can be uptaken from the nasal mucosa or olfactory pathways into the peripheral and central neurons; for the latter, Cd can increase the blood brain barrier (BBB) permeability. However, mechanisms underlying Cd neurotoxicity remain not completely understood. Effect of Cd neurotransmitter, oxidative damage, interaction…

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Topics & keywords

Topics
Keywords
  • Neurotoxicity
  • Cadmium
  • Central nervous system
  • In vivo
  • Blood–brain barrier
  • Chemistry
  • Neurotransmitter
  • Nervous system
UN Sustainable Development Goals
  • Life in Land
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