miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
Centre National de la Recherche Scientifique · Howard Hughes Medical Institute · +3 more institutions
Abstract
Gemin3 is a DEAD-box RNA helicase that binds to the Survival of Motor Neurons (SMN) protein and is a component of the SMN complex, which also comprises SMN, Gemin2, Gemin4, Gemin5, and Gemin6. Reduction in SMN protein results in Spinal muscular atrophy (SMA), a common neurodegenerative disease. The SMN complex has critical functions in the assembly/restructuring of diverse ribonucleoprotein (RNP) complexes. Here we report that Gemin3 and Gemin4 are also in a separate complex that contains eIF2C2, a member of the Argonaute protein family. This novel complex is a large approximately 15S RNP that contains numerous microRNAs (miRNAs). We describe 40 miRNAs, a few of which are identical to recently described human…
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Authors
9- ZPZissimos P. MourelatosCorresponding
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, University of Southern Denmark, University of Pennsylvania
- JDJosée Dostie
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, University of Southern Denmark, Institut de Biologie du Développement Marseille, University of Pennsylvania
- SPSergey Paushkin
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, University of Southern Denmark, Institut de Biologie du Développement Marseille, University of Pennsylvania
- ASAnup Sharma
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, University of Southern Denmark, Institut de Biologie du Développement Marseille, University of Pennsylvania
- BCBernard Charroux
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, University of Southern Denmark, Institut de Biologie du Développement Marseille, University of Pennsylvania
Topics & keywords
- Biology
- Ribonucleoprotein
- Spinal muscular atrophy
- Drosha
- microRNA
- Helicase
- RNA-binding protein
- Cell biology