Spatial memory, recognition memory, and the hippocampus

There is wide agreement that spatial memory is dependent on the integrity of the hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of object recognition memory is not as clear. We examined the relationship between hippocampal lesion size and both spatial memory and object recognition memory in rats. Spatial memory was impaired after bilateral dorsal hippocampal lesions that encompassed 30-50% total volume, and as lesion size increased from 50% to approximately 100% of total hippocampal volume, performance was similarly impaired. In contrast, object recognition was intact after dorsal hippocampal lesions that damaged 50-75% of total hippocampal volume and was impaired only…

• NS
  National Science Foundation
• UD
  U.S. Department of Veterans Affairs
• JS
  James S. McDonnell Foundation
• NA
  National Alliance for Research on Schizophrenia and Depression
• NI
  National Institute of Mental Health

  Awards: P50 AG05131, AG05131