The role of substance P in inflammatory disease

O’Connor, Terence M.; O’Connell, Joseph; O’Brien, Darren I.; Goode, Triona; Bredin, C. P.; Shanahan, Fergus

doi:10.1002/jcp.20061

reviewJournal of Cellular PhysiologyMar 19, 2004BRONZE OA

The role of substance P in inflammatory disease

TMTerence M. O’Connor JOJoseph O’Connell DIDarren I. O’Brien TGTriona Goode CPC. P. Bredin

University College Cork · Cork University Hospital

Indexed incrossref

Abstract

Abstract The diffuse neuroendocrine system consists of specialised endocrine cells and peptidergic nerves and is present in all organs of the body. Substance P (SP) is secreted by nerves and inflammatory cells such as macrophages, eosinophils, lymphocytes, and dendritic cells and acts by binding to the neurokinin‐1 receptor (NK‐1R). SP has proinflammatory effects in immune and epithelial cells and participates in inflammatory diseases of the respiratory, gastrointestinal, and musculoskeletal systems. Many substances induce neuropeptide release from sensory nerves in the lung, including allergen, histamine, prostaglandins, and leukotrienes. Patients with asthma are hyperresponsive to SP and NK‐1R expression is…

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776

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FWCI: 9.98
Percentile: 100%
References: 222

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Authors

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Topics & keywords

Topics

Keywords

Proinflammatory cytokine
Substance P
Immunology
Medicine
Inflammation
Immune system
Inflammatory bowel disease
Neurokinin A

UN Sustainable Development Goals

Good health and well-being

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