The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma
University of Arkansas for Medical Sciences · Cancer Research And Biostatistics
Indexed incrossrefpubmed
Abstract
Background
Myeloma cells may secrete factors that affect the function of osteoblasts, osteoclasts, or both.
Methods
We subjected purified plasma cells from the bone marrow of patients with newly diagnosed multiple myeloma and control subjects to oligonucleotide microarray profiling and biochemical and immunohistochemical analyses to identify molecular determinants of osteolytic lesions.
Citation impact
1,503
total citations
- FWCI
- 24.68
- Percentile
- 100%
- References
- 40
Citations per year
Authors
7Topics & keywords
Topics
Keywords
- DKK1
- Bone marrow
- Multiple myeloma
- Pathology
- Medicine
- Osteoblast
- Wnt signaling pathway
- Immunohistochemistry
No related works found for this paper.