articleJournal of NeuroscienceMar 1, 2006BRONZE OA

Cortical and Subcortical Contributions to Stop Signal Response Inhibition: Role of the Subthalamic Nucleus

ARAdam R. AronRARussell A. Poldrack

University of California, Los Angeles

PubMed
Indexed incrossrefpubmed

Abstract

Suppressing an already initiated manual response depends critically on the right inferior frontal cortex (IFC), yet it is unclear how this inhibitory function is implemented in the motor system. It has been suggested that the subthalamic nucleus (STN), which is a part of the basal ganglia, may play a role because it is well placed to suppress the "direct" fronto-striatal pathway that is activated by response initiation. In two experiments, we investigated this hypothesis with functional magnetic resonance imaging and a Stop-signal task. Subjects responded to Go signals and attempted to inhibit the initiated response to occasional Stop signals. In experiment 1, Going significantly activated frontal, striatal,…

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Topics & keywords

Topics
Keywords
  • Subthalamic nucleus
  • Neuroscience
  • Basal ganglia
  • Functional magnetic resonance imaging
  • Stop signal
  • Indirect pathway of movement
  • Direct pathway of movement
  • Psychology
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