Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
University of California San Diego · The Institute of Medical Science, Asahi Life Foundation · +2 more institutions
Abstract
Hepatocellular carcinoma (HCC), the most common liver cancer, occurs mainly in men. Similar gender disparity is seen in mice given a chemical carcinogen, diethylnitrosamine (DEN). DEN administration caused greater increases in serum interleukin-6 (IL-6) concentration in males than it did in females. Furthermore, ablation of IL-6 abolished the gender differences in hepatocarcinogenesis in mice. DEN exposure promoted production of IL-6 in Kupffer cells (KCs) in a manner dependent on the Toll-like receptor adaptor protein MyD88, ablation of which also protected male mice from DEN-induced hepatocarcinogenesis. Estrogen inhibited secretion of IL-6 from KCs exposed to necrotic hepatocytes and reduced circulating…
Citation impact
- FWCI
- 59.45
- Percentile
- 100%
- References
- 28
Authors
7- WEWillscott E. Naugler
University of California San Diego, The Institute of Medical Science, Asahi Life Foundation, Gene Therapy Laboratory, Newcastle University
- TSToshiharu Sakurai
University of California San Diego, The Institute of Medical Science, Asahi Life Foundation, Gene Therapy Laboratory, Newcastle University
- SKSunhwa Kim
University of California San Diego, The Institute of Medical Science, Asahi Life Foundation, Gene Therapy Laboratory, Newcastle University
- SMShin Maeda
University of California San Diego, The Institute of Medical Science, Asahi Life Foundation, Gene Therapy Laboratory, Newcastle University
- KKKyounghyun Kim
University of California San Diego, The Institute of Medical Science, Asahi Life Foundation, Gene Therapy Laboratory, Newcastle University
Topics & keywords
- Liver cancer
- Hepatocellular carcinoma
- Endocrinology
- Estrogen
- Carcinogen
- Internal medicine
- Secretion
- Estrogen receptor
- Good health and well-being