JAKs and STATs in Immunity, Immunodeficiency, and Cancer

O’Shea, John J.; Holland, Steven M.; Staudt, Louis M.

doi:10.1056/nejmra1202117

reviewNew England Journal of MedicineJan 10, 2013GREEN OA

JAKs and STATs in Immunity, Immunodeficiency, and Cancer

JJJohn J. O’Shea SMSteven M. Holland LMLouis M. Staudt

National Institute of Arthritis and Musculoskeletal and Skin Diseases · National Institutes of Health · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

A large number of cytokines signal through the JAK–STAT pathway. Abnormal function of this pathway may lead to a variety of diseases. Targeting the defects in this signaling pathway has already led to treatment advances, and further advances are likely.

Citation impact

915

total citations

FWCI: 39.89
Percentile: 100%
References: 101

Citations per year

Authors

JJ
John J. O’SheaCorresponding
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
SM
Steven M. Holland
National Institute of Allergy and Infectious Diseases
LM
Louis M. Staudt
National Institutes of Health, National Cancer Institute

Topics & keywords

Topics

Cytokine Signaling Pathways and Interactions100%
Myeloproliferative Neoplasms: Diagnosis and Treatment100%
Chronic Lymphocytic Leukemia Research100%

Keywords

Medicine
Signal transduction
Immunity
Immunology
Immunodeficiency
Cancer research
Primary immunodeficiency
Cancer

UN Sustainable Development Goals

Good health and well-being

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