Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
Indexed incrossrefpubmed
Abstract
Neutrophils respond to myocardial ischemia-reperfusion in a manner similar to the bacterial invasion of a host. The inflammatory-like response that follows the onset of reperfusion involves intense interactions with the coronary vascular endothelium, arterial wall, and cardiomyocytes in a very well-choreographed manner. Neutrophils have been implicated as primary and secondary mediators of lethal injury after reperfusion to coronary vascular endothelium and cardiomyocytes. The involvement of neutrophils in the pathogenesis of lethal myocardial injury has been inferred from (1) their presence and accumulation in reperfused myocardium in temporal agreement with injury induced, (2) the armamentarium of toxic…
Citation impact
667
total citations
- FWCI
- 9.79
- Percentile
- 100%
- References
- 220
Citations per year
Authors
1Topics & keywords
Topics
Keywords
- Pathogenesis
- Medicine
- Reperfusion injury
- Ischemia
- Endothelium
- Inflammation
- Cardiology
- Immunology
UN Sustainable Development Goals
- Good health and well-being
No related works found for this paper.