A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic‐resistant  Pseudomonas aeruginosa ; a preliminary report of efficacy

Wright, A.; Hawkins, Catherine; Änggård, Erik; Harper, David R.

doi:10.1111/j.1749-4486.2009.01973.x

articleClinical OtolaryngologyJul 23, 2009BRONZE OA

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic‐resistant Pseudomonas aeruginosa ; a preliminary report of efficacy

AWA. Wright CHCatherine Hawkins EÄErik Änggård DRDavid R. Harper

Royal National Throat Nose and Ear Hospital · University College London · +1 more institution

PubMed

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Abstract

Objectives

To evaluate the efficacy and safety of a therapeutic bacteriophage preparation (Biophage-PA) targeting antibiotic-resistant Pseudomonas aeruginosa in chronic otitis.

Design

Randomised, double-blind, placebo-controlled Phase I/II clinical trial approved by UK Medicines and Healthcare products Regulatory Agency (MHRA) and the Central Office for Research Ethics Committees (COREC) ethical review process.

Citation impact

835

total citations

FWCI: 20.08
Percentile: 100%
References: 16

Citations per year

Authors

4

Topics & keywords

Topics

Keywords

Medicine
Pseudomonas aeruginosa
Placebo
Clinical trial
Internal medicine
Antibiotics
Erythema
Visual analogue scale

UN Sustainable Development Goals

Good health and well-being

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