Matrix Metalloproteinases and Other Matrix Proteinases in Relation to Cariology: The Era of ‘Dentin Degradomics'

Dentin organic matrix, with type I collagen as the main component, is exposed after demineralization in dentinal caries, erosion or acidic conditioning during adhesive composite restorative treatment. This exposed matrix is prone to slow hydrolytic degradation by host collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins. Here we review the recent findings demonstrating that inhibition of salivary or dentin endogenous collagenolytic enzymes may provide preventive means against progression of caries or erosion, just as they have been shown to retain the integrity and improve the longevity of resin composite filling bonding to dentin. This paper also presents the case that the organic…

• FD
  Fondation de l'Avenir pour la Recherche Médicale Appliquée
• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo
• AO
  Academy of Finland

  Award: 256990
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico

  Awards: 401347/2012-5, 2012-5