Imaging β-amyloid burden in aging and dementia

Rowe, C. C.; Ng, Sally; Ackermann, Uwe; Gong, S.; Pike, Kerryn E.; Savage, Greg; Cowie, Tiffany; Dickinson, Katherine L.; Maruff, Paul; Darby, D; Smith, Clare L.; Woodward, Mark; Merory, John; Tochon‐Danguy, Henri; O’Keefe, Graeme; Klunk, William E.; Mathis, Chester A.; Price, Julie C.; Masters, Colin L.; Villemagne, Victor L.

doi:10.1212/01.wnl.0000261919.22630.ea

articleNeurologyMay 14, 2007Closed access

Imaging β-amyloid burden in aging and dementia

CCC. C. Rowe SNSally Ng UAUwe Ackermann SGS. Gong KEKerryn E. Pike

University of Melbourne

PubMed

Indexed incrossrefpubmed

Abstract

Objective

To compare brain beta-amyloid (Abeta) burden measured with [(11)C]Pittsburgh Compound B (PIB) PET in normal aging, Alzheimer disease (AD), and other dementias.

Methods

Thirty-three subjects with dementia (17 AD, 10 dementia with Lewy bodies [DLB], 6 frontotemporal dementia [FTD]), 9 subjects with mild cognitive impairment (MCI), and 27 age-matched healthy control subjects (HCs) were studied. Abeta burden was quantified using PIB distribution volume ratio.

Citation impact

1,105

total citations

FWCI: 53.99
Percentile: 100%
References: 60

Citations per year

Authors

20

Topics & keywords

Topics

Keywords

Dementia
Amyloid (mycology)
Medicine
Amyloid β
Neuroscience
Alzheimer's disease
Psychology
Pathology

UN Sustainable Development Goals

Good health and well-being

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