A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
Institute of Immunology · The University of Texas Southwestern Medical Center
Abstract
The y-linked autoimmune accelerating (yaa) locus is a potent autoimmune disease allele. Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X-linked genes that included Tlr7. FISH analysis demonstrated the translocation of this segment onto the yaa chromosome. The resulting overexpression of Tlr7 increased in vitro responses to Toll-like receptor (TLR) 7 signaling in all yaa-bearing males. B6.yaa mice are not overtly autoimmune, but the addition of Sle1, which contains the autoimmune-predisposing Slam/Cd2 haplotype, causes the development of fatal lupus with numerous immunological aberrations. B6.Sle1yaa CD4 T cells develop the molecular signature for T(FH) cells and also…
Citation impact
- FWCI
- 16.10
- Percentile
- 100%
- References
- 49
Authors
12- SSSrividya SubramanianCorresponding
Institute of Immunology, The University of Texas Southwestern Medical Center
- KTKatalin Tus
Institute of Immunology, The University of Texas Southwestern Medical Center
- QLQuan‐Zhen Li
Institute of Immunology
- AWAndrew Wang
Institute of Immunology, The University of Texas Southwestern Medical Center
- XTXiang-Hong Tian
Institute of Immunology, The University of Texas Southwestern Medical Center
Topics & keywords
- TLR7
- Biology
- Autoimmunity
- Innate immune system
- Immunology
- Immune system
- Acquired immune system
- Autoimmune disease