Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Sawcer, Stephen; Ban, Maria; Kemppinen, Anu; Compston, Alastair; Skidmore, Sheila; Baker, Amie; Freeman, Colin; Pirinen, Matti; Band, Gavin; Strange, Amy; McVean, Gil; Donnelly, Peter; Su, Zhan; Giannoulatou, Eleni; Spencer, Chris C. A.; Bellenguez, Céline; Hellenthal, Garrett; Rautanen, Anna; Patsopoulos, Nikolaos A.; Bakker, Paul I. W. de; Jager, Philip L. De; Daly, Mark J.; Ardlie, Kristin; Patsopoulos, Nikolaos A.; Hafler, David A.; Aubin, Cristin; Bakker, Paul I. W. de; Jager, Philip L. De; Patsopoulos, Nikolaos A.; Pobywajlo, Susan; Donnelly, Peter; Moutsianas, Loukas; Dilthey, Alexander; Whittaker, Pamela; Widaa, Sara; Hunt, Sarah; Waller, Matthew; Ravindrarajah, Rathi; Edkins, Sarah; Potter, Simon; Hammond, Naomi; Bumpstead, Suzannah J.; Gray, Emma; Ricketts, Michelle; Deloukas, Panos; Langford, Cordelia; Palotie, Aarno; Perez, M. L.; Gillman, Matthew; Blackburn, Hannah; McCann, Owen T; Gwilliam, Rhian; Liddle, Jennifer; Dronov, Serge; Weston, Paul A.; Jayakumar, Alagurevathi; Stewart, Graeme J.; Heard, Rob N.; Booth, David R.; Dobosi, Rita; Dubois, Bénédicte; Clysters, Katleen; Goris, An; Oturai, Annette; Sørensen, Per Soelberg; Sellebjerg, Finn; Søndergaard, Helle Bach; Palotie, Aarno; Sulonen, Anna-Maija; Saarela, Janna; Leppä, Virpi; Fontaine, Bertrand; Fontenille, Claire; Cournu‐Rebeix, Isabelle; Hemmer, Bernhard; Hoshi, Muna; Buck, Dorothea; Cepok, Sabine; Winkelmann, Juliane; Berthele, Achim; Zipp, Frauke; Zipp, Frauke; Martinꝉ, Roland; Roesner, Sabine; Leslie, Stephen; Hawkins, Stanley; D’alfonso, Sandra; Bergamaschi, Laura; Comı, Gıancarlo; Rodegher, Mariaemma; Martinelli, Vittorio; Esposito, Federica; Boneschi, Filippo Martinelli; Harbo, Hanne F.; Mero, Inger-Lise; Celius, Elisabeth Gulowsen; Smestad, C.; Lorentzen, Åslaug Rudjord; Harbo, Hanne F.; Spurkland, Anne; Mycko, Marcin P.; Selmaj, Krzysztof; Tronczyńska, E.; Montalbán, Xavier; Comabella, Manuel; Kockum, Ingrid; Olsson, Tomas; Hillert, Jan; Jagodic, Maja; Link, Jenny; Piehl, Fredrik; Sundqvist, Emilie; Bomfim, Izaura Lima; Strange, Richard C.; Mihalova, Tania; Abraham, Roby; Hawkins, Clive; Hobart, Jeremy; Vickery, Jane; Ingram, Wendy; Zajicek, John; Pickersgill, Trevor; Cossburn, M.; Baker, K.; Robertson, Neil P.; Ingram, Gillian; Ramsay, Patricia P.; Quach, Hong; Barcellos, Lisa F.; Barcellos, Lisa F.; Shen, Ling; Schaefer, Catherine; Simms-Acuna, Brigid; Bernstein, Allan; Alfredsson, Lars; Santaniello, Adam; Cree, Bruce; Lincoln, Robin; Hauser, Stephen L.; Oksenberg, Jorge R.; Baranzini, Sergio E.; Gomez, Refujia; Bergamaschi, Roberto; Boggild, Mike; Glessner, Joseph; Sleiman, Patrick M. A.; Mentch, Frank; Chiavacci, Rosetta; Bradfield, Jonathan P.; Zhang, Haitao; Kim, Cecilia; Grant, Struan F. A.; Wang, Kai; Håkonarson, Håkon; Brassat, David; Broadley, Simon; Butzkueven, Helmut; Kilpatrick, Trevor J.; Rubio, Justin P.; Marriott, Mark; Butzkueven, Helmut; Kilpatrick, Trevor J.; Marriott, Mark; Tubridy, Niall; Butzkueven, Helmut; Butzkueven, Helmut; Capra, Ruggero; Kermode, Allan G.; Carroll, William M.; Cavalla, Paola; Clerget‐Darpoux, Françoise; Cox, Mathew; Lechner‐Scott, Jeannette; Scott, Rodney J.; Cozen, Wendy; Islam, Talat; Mack, Thomas M.; Piccio, Laura; Cross, Anne H.; Macciardi, Fabìo; Salvi, Erika; Lupoli, Sara; Cusi, Daniele; Jager, Philip L. De; Daly, Mark J.; Ivinson, Adrian J.; Daly, Mark J.; Ollier, William; Dixon, Katherine; Davis, Emma; Bakker, Paul I. W. de; Bakker, Paul I. W. de; Debouverie, Marc; D’hooghe, Marie Beatrice; Ellinghaus, David; Franke, André; Schreiber, Stefan; Wittig, Michael; Elovaara, Irina; Elovaara, Irina; Stankovich, Jim; Foote, Simon J.; Taylor, Bruce; Galimberti, Daniela; Ghezzi, Angelo; Gout, Olivier; Graham, Colin A.; Grant, Struan F.A.; Sleiman, Patrick M. A.; Zhang, Haitao; Wang, Kai; Hakonarson, Hakon; Hakonarson, Hakon; Grant, Struan F. A.; Guerini, Franca Rosa; Hall, Per; Hamsten, Anders; Larsson, Malin; Hartung, Hans-Peter; Lathrop, Mark; Heath, Simon; Infante‐Duarte, Carmen; Kabesch, Michael; Kilpatrick, Trevor J.; Klopp, Norman; Wichmann, H-Erich; Rückert, Ina-Maria; Koivisto, Keijo; Lechner‐Scott, Jeannette; Naldi, Paola; Leone, Maurizio; Leppä, Virpi; Sulonen, Anna-Maija; Liljedahl, Ulrika; Syvänen, Ann-Christine; Liu, Jianjun; Lorentzen, Åslaug Rudjord; Mero, Inger-Lise; Lupoli, Sara; Macciardi, Fabìo; Mason, Deborah; Pericak‐Vance, Margaret A.; McCauley, Jacob L.; Mottershead, John; Mottershead, John; Myhr, Kjell-Morten; Myhr, Kjell-Morten; Page, Alison; Palotie, Aarno; Palotie, Aarno; Pelletier, Jean; Reunanen, Mauri; Reynolds, Richard; Rioux, John D.; Salvetti, Marco; Taddeo, Francesca De; Salvi, Erika; Schreiber, Stefan; Schulze, Christian; Sexton, David; Zuvich, Rebecca L.; Haines, Jonathan L.; Blackwell, Jenefer M.; Blackwell, Jenefer M.; Tienari, Pentti J.; Bramon, Elvira; Tourbah, Ayman; Brown, Matthew A.; Casas, Juan P.; Tubridy, Niall; Corvin, Aiden; Jankowski, Janusz; Villoslada, Pablo; Markus, Hugh S.; Trembath, Richard C.; Mathew, Christopher G.; Wason, James; Palmer, Colin N. A.; Wichmann, H-Erich; Wichmann, H-Erich; Plomin, Robert; Willoughby, Ernest; Winkelmann, Juliane; Winkelmann, Juliane; Wittig, Michael; Yaouanq, Jacqueline; Viswanathan, Ananth C.; Wood, Nicholas; Duncanson, Audrey; Ivinson, Adrian J.; Hafler, David A.

doi:10.1038/nature10251

articleNatureAug 1, 2011BRONZE OA

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

SSStephen Sawcer MBMaria Ban AKAnu Kemppinen ACAlastair Compston SSSheila Skidmore

University of Cambridge · Addenbrooke's Hospital · +160 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

2,733

total citations

FWCI: 112.70
Percentile: 100%
References: 27

Citations per year

Authors

291

SS
Stephen SawcerCorresponding
University of Cambridge, Addenbrooke's Hospital
MB
Maria Ban
University of Oxford, Addenbrooke's Hospital
AK
Anu Kemppinen
University of Oxford, Addenbrooke's Hospital
AC
Alastair Compston
University of Oxford, Addenbrooke's Hospital
SS
Sheila Skidmore
Harvard University Press, Addenbrooke's Hospital

Topics & keywords

Topics

Cytokine Signaling Pathways and Interactions99%
Multiple Sclerosis Research Studies99%
Immune responses and vaccinations98%

Keywords

Multiple sclerosis
Primary (astronomy)
Immune system
Biology
Neuroscience
Genetics
Medicine
Immunology

No related works found for this paper.

Funding

SG
Susan G. Komen for the Cure
B
Biogen
KP
Kaiser Permanente
CH
Children's Hospital of Philadelphia
FC
Fondazione CRT
FP
Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
IO
Institute of Clinical and Translational Sciences
S
Scleroseforeningen
HJ
Helsingin ja Uudenmaan Sairaanhoitopiiri
WT
Wellcome Trust
Awards: 075491/Z/04, 085475/Z/08/Z, 085475, 068545/Z/02, G0000934, 085475/B/08/Z
NI
National Institute for Health and Care Research
MS
Multiple Sclerosis Society
MS
Multiple Sclerosis Australia
DF
Deutsche Forschungsgemeinschaft
IN
Institut National de la Santé et de la Recherche Médicale
FF
Forskningsrådet för Arbetsliv och Socialvetenskap
AO
Academy of Finland
FW
Fonds Wetenschappelijk Onderzoek
MD
Ministero della Salute
Award: 502/92
H
Hjärnfonden
KO
Knut och Alice Wallenbergs Stiftelse
SL
Stockholms Läns Landsting
Award: 562183
NF
Norges Forskningsråd
RP
Regione Piemonte
HU
Haukeland Universitetssjukehus
VR
Vlaamse regering
NI
National Institutes of Health
Awards: RR024992, G0000934, 075491/Z/04, 068545/Z/02
MR
Medical Research Council
Awards: MC_EX_G0800860, 068545/Z/02, G0000934
NH
National Health and Medical Research Council
Award: G0000934
HZ
Helmholtz Zentrum München