Bacteria–host communication: The language of hormones
University of Maryland, Baltimore · Southwestern Medical Center · +2 more institutions
Abstract
The interbacterial communication system known as quorum sensing (QS) utilizes hormone-like compounds referred to as autoinducers to regulate bacterial gene expression. Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 is the agent responsible for outbreaks of bloody diarrhea in several countries. We previously proposed that EHEC uses a QS regulatory system to "sense" that it is within the intestine and activate genes essential for intestinal colonization. The QS system used by EHEC is the LuxS/autoinducer 2 (AI-2) system extensively involved in interspecies communication. The autoinducer AI-2 is a furanosyl borate diester whose synthesis depends on the enzyme LuxS. Here we show that an EHEC luxS…
Citation impact
- FWCI
- 21.82
- Percentile
- 100%
- References
- 42
Authors
5- VSVanessa SperandioCorresponding
University of Maryland, Baltimore, Southwestern Medical Center, University of Maryland, College Park, The University of Texas Southwestern Medical Center
- AGAlfredo G. Torres
University of Maryland, Baltimore, Southwestern Medical Center, University of Maryland, College Park, The University of Texas Southwestern Medical Center
- BBBruce B. Jarvis
University of Maryland, Baltimore, Southwestern Medical Center, University of Maryland, College Park, The University of Texas Southwestern Medical Center
- JPJames P. Nataro
University of Maryland, Baltimore, Southwestern Medical Center, University of Maryland, College Park, The University of Texas Southwestern Medical Center
- JBJames B. Kaper
University of Maryland, Baltimore, Southwestern Medical Center, University of Maryland, College Park, The University of Texas Southwestern Medical Center
Topics & keywords
- Autoinducer
- Quorum sensing
- Microbiology
- Biology
- Escherichia coli
- Signal transduction
- Bacteria
- Cell signaling