reviewBiochimica et Biophysica Acta (BBA) - General SubjectsJan 10, 2014HYBRID OA

Extracellular matrix: A dynamic microenvironment for stem cell niche

FGFrancesca GattazzoAUAnna UrciuoloPBPaolo Bonaldo

University of Padua

PubMed
Indexed incrossrefpubmed

Abstract

BACKGROUND: Extracellular matrix (ECM) is a dynamic and complex environment characterized by biophysical, mechanical and biochemical properties specific for each tissue and able to regulate cell behavior. Stem cells have a key role in the maintenance and regeneration of tissues and they are located in a specific microenvironment, defined as niche. SCOPE OF REVIEW: We overview the progresses that have been made in elucidating stem cell niches and discuss the mechanisms by which ECM affects stem cell behavior. We also summarize the current tools and experimental models for studying ECM-stem cell interactions. MAJOR CONCLUSIONS: ECM represents an essential player in stem cell niche, since it can directly or…

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1,292
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Authors

3

Topics & keywords

Topics
Keywords
  • Stem cell
  • Extracellular matrix
  • Cell biology
  • Niche
  • Biology
  • Stem cell niche
  • Regeneration (biology)
  • Adult stem cell
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