An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Howard Hughes Medical Institute · Johns Hopkins University · +4 more institutions
Abstract
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and deletions using high-density oligonucleotide arrays, and performed gene expression analyses using next-generation sequencing technologies in 22 human tumor samples. This comprehensive analysis led to the discovery of a variety of genes that were not known to be altered in GBMs. Most notably, we found recurrent mutations in the active site of isocitrate dehydrogenase 1 (IDH1) in 12% of GBM patients. Mutations in IDH1 occurred in a large fraction of young patients and in most patients with secondary…
Citation impact
- FWCI
- 169.39
- Percentile
- 100%
- References
- 51
Authors
33- DWD. Williams ParsonsCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Baylor College of Medicine, Johns Hopkins Bayview Medical Center, Sidney Kimmel Cancer Center, Pediatric Brain Tumor Foundation
- SJSiân JonesCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Baylor College of Medicine, Johns Hopkins Bayview Medical Center, Sidney Kimmel Cancer Center, Pediatric Brain Tumor Foundation
- XZXiaosong ZhangCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Baylor College of Medicine, Johns Hopkins Bayview Medical Center, Sidney Kimmel Cancer Center, Pediatric Brain Tumor Foundation
- JLJimmy LinCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Baylor College of Medicine, Johns Hopkins Bayview Medical Center, Sidney Kimmel Cancer Center, Pediatric Brain Tumor Foundation
- RLRebecca LearyCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Baylor College of Medicine, Johns Hopkins Bayview Medical Center, Sidney Kimmel Cancer Center, Pediatric Brain Tumor Foundation
Topics & keywords
- IDH1
- Isocitrate dehydrogenase
- Glioblastoma
- Gene
- Biology
- Genetics
- Computational biology
- Coding region
- Good health and well-being