Direct Human Cartilage Repair Using Three-Dimensional Bioprinting Technology
Scripps Research Institute · Scripps Clinic
Abstract
Current cartilage tissue engineering strategies cannot as yet fabricate new tissue that is indistinguishable from native cartilage with respect to zonal organization, extracellular matrix composition, and mechanical properties. Integration of implants with surrounding native tissues is crucial for long-term stability and enhanced functionality. In this study, we developed a bioprinting system with simultaneous photopolymerization capable for three-dimensional (3D) cartilage tissue engineering. Poly(ethylene glycol) dimethacrylate (PEGDMA) with human chondrocytes were printed to repair defects in osteochondral plugs (3D biopaper) in layer-by-layer assembly. Compressive modulus of printed PEGDMA was 395.73±80.40…
Citation impact
- FWCI
- 22.36
- Percentile
- 100%
- References
- 34
Authors
5Topics & keywords
- Cartilage
- Biomedical engineering
- Tissue engineering
- Materials science
- Chondrogenesis
- Extracellular matrix
- Biomaterial
- 3D bioprinting