Distinct patterns of brain activity in young carriers of the APOE -ε4 allele
University of Oxford · Wellcome Centre for Integrative Neuroimaging · +3 more institutions
Abstract
The APOE epsilon4 allele is a risk factor for late-life pathological changes that is also associated with anatomical and functional brain changes in middle-aged and elderly healthy subjects. We investigated structural and functional effects of the APOE polymorphism in 18 young healthy APOE epsilon4-carriers and 18 matched noncarriers (age range: 20-35 years). Brain activity was studied both at rest and during an encoding memory paradigm using blood oxygen level-dependent fMRI. Resting fMRI revealed increased "default mode network" (involving retrosplenial, medial temporal, and medial-prefrontal cortical areas) coactivation in epsilon4-carriers relative to noncarriers. The encoding task produced greater…
Citation impact
- FWCI
- 36.00
- Percentile
- 100%
- References
- 60
Authors
9- NFNicola FilippiniCorresponding
University of Oxford, Wellcome Centre for Integrative Neuroimaging, Centro San Giovanni di Dio Fatebenefratelli
- BJBradley J. MacIntosh
University of Oxford, Wellcome Centre for Integrative Neuroimaging
- MHM. Hough
University of Oxford, Wellcome Centre for Integrative Neuroimaging
- GMGuy M. Goodwin
- GBGiovanni B. Frisoni
Centro San Giovanni di Dio Fatebenefratelli
Topics & keywords
- Apolipoprotein E
- Default mode network
- Allele
- Retrosplenial cortex
- Neuroscience
- Hippocampal formation
- Prefrontal cortex
- Episodic memory