Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress
University of Colorado Denver · Instituto Nacional de Cardiología · +6 more institutions
Indexed incrossrefdoajpubmed
Abstract
Background
Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown.
Results
Hepatocytes exposed to uric acid developed mitochondrial dysfunction and increased de novo lipogenesis, and its blockade prevented fructose-induced lipogenesis.
Citation impact
700
total citations
- FWCI
- 12.15
- Percentile
- 100%
- References
- 57
Citations per year
Authors
16- MAMiguel A. LanaspaCorresponding
University of Colorado Denver
- LGLaura Gabriela Sánchez‐Lozada
Instituto Nacional de Cardiología, University of Colorado Denver
- YCYea-Jin Choi
Ewha Womans University Medical Center
- CCChristina Cicerchi
Vyne Therapeutics (United States), University of Colorado Denver
- MKMehmet Kanbay
Kayseri Eğitim ve Araştırma Hastanesi
Topics & keywords
Topics
Keywords
- Steatosis
- Oxidative stress
- Uric acid
- Oxidative phosphorylation
- Mitochondrion
- Chemistry
- Biochemistry
- Internal medicine
UN Sustainable Development Goals
- Good health and well-being
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