Functional Connectivity and Brain Networks in Schizophrenia

Schizophrenia has often been conceived as a disorder of connectivity between components of large-scale brain networks. We tested this hypothesis by measuring aspects of both functional connectivity and functional network topology derived from resting-state fMRI time series acquired at 72 cerebral regions over 17 min from 15 healthy volunteers (14 male, 1 female) and 12 people diagnosed with schizophrenia (10 male, 2 female). We investigated between-group differences in strength and diversity of functional connectivity in the 0.06-0.125 Hz frequency interval, and some topological properties of undirected graphs constructed from thresholded interregional correlation matrices. In people with schizophrenia,…

• BS
  Bristol-Myers Squibb
• CD
  Centro de Investigación Biomédica en Red de Salud Mental
• NI
  National Institutes of Health
• ID
  Instituto de Salud Carlos III
• NI
  National Institute of Mental Health
• NI
  National Institute of Biomedical Imaging and Bioengineering