Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

Protein structure underlies essential biological processes and provides a blueprint for molecular mimicry that drives drug discovery. Although small molecules represent the lion's share of agents that target proteins for therapeutic benefit, there remains no substitute for the natural properties of proteins and their peptide subunits in the majority of biological contexts. The peptide α-helix represents a common structural motif that mediates communication between signaling proteins. Because peptides can lose their shape when taken out of context, developing chemical interventions to stabilize their bioactive structure remains an active area of research. The all-hydrocarbon staple has emerged as one such…

• LA
  Leukemia and Lymphoma Society

  Award: 7009-12
• NI
  National Institutes of Health

  Awards: 5R01 GM090299, 1R01 AI084102, 5R01 CA050239