Abnormal Brain Development in Newborns with Congenital Heart Disease
University of California, San Francisco · University of British Columbia · +2 more institutions
Abstract
Congenital heart disease in newborns is associated with global impairment in development. We characterized brain metabolism and microstructure, as measures of brain maturation, in newborns with congenital heart disease before they underwent heart surgery.
We studied 41 term newborns with congenital heart disease--29 who had transposition of the great arteries and 12 who had single-ventricle physiology--with the use of magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and diffusion tensor imaging (DTI) before cardiac surgery. We calculated the ratio of N-acetylaspartate to choline (which increases with brain maturation), the ratio of lactate to choline (which decreases with maturation), average diffusivity (which decreases with maturation), and fractional anisotropy of white-matter tracts (which increases with maturation). We compared these findings with those in 16 control newborns of a similar gestational age.
Citation impact
- FWCI
- 18.06
- Percentile
- 100%
- References
- 49
Authors
11- SPSteven P. MillerCorresponding
University of California, San Francisco, University of British Columbia
- PSPatrick S. McQuillen
University of California, San Francisco, University of San Francisco
- SEShannon E. G. Hamrick
University of San Francisco, University of California, San Francisco, Emory University
- DXDuan Xu
University of San Francisco, University of California, San Francisco
- DVDavid V. Glidden
University of San Francisco, University of California, San Francisco
Topics & keywords
- Medicine
- Fractional anisotropy
- Heart disease
- Choline
- Diffusion MRI
- White matter
- Cardiology
- Gestational age
- Good health and well-being