Reconceptualizing functional brain connectivity in autism from a developmental perspective

While there is almost universal agreement amongst researchers that autism is associated with alterations in brain connectivity, the precise nature of these alterations continues to be debated. Theoretical and empirical work is beginning to reveal that autism is associated with a complex functional phenotype characterized by both hypo- and hyper-connectivity of large-scale brain systems. It is not yet understood why such conflicting patterns of brain connectivity are observed across different studies, and the factors contributing to these heterogeneous findings have not been identified. Developmental changes in functional connectivity have received inadequate attention to date. We propose that discrepancies…

• NI
  National Institutes of Health

  Awards: MH084164, DC011095, K01MH092288
• NI
  National Institute of Mental Health

  Awards: MH084164, K01MH092288