articleJournal of Amino AcidsFeb 28, 2012HYBRID OA

Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions

VIVolodymyr I. Lushchak

Vasyl Stefanyk Carpathian National University

PubMed
Indexed incrossrefpubmed

Abstract

Glutathione (GSH) is a tripeptide, which has many biological roles including protection against reactive oxygen and nitrogen species. The primary goal of this paper is to characterize the principal mechanisms of the protective role of GSH against reactive species and electrophiles. The ancillary goals are to provide up-to-date knowledge of GSH biosynthesis, hydrolysis, and utilization; intracellular compartmentalization and interorgan transfer; elimination of endogenously produced toxicants; involvement in metal homeostasis; glutathione-related enzymes and their regulation; glutathionylation of sulfhydryls. Individual sections are devoted to the relationships between GSH homeostasis and pathologies as well as…

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1,250
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100%
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Topics & keywords

Topics
Keywords
  • Glutathione
  • Homeostasis
  • Compartmentalization (fire protection)
  • Reactive oxygen species
  • Biochemistry
  • Tripeptide
  • Chemistry
  • Medicine
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