articleNew England Journal of MedicineJun 1, 2005BRONZE OA

Effect of VKORC1 Haplotypes on Transcriptional Regulation and Warfarin Dose

MJMark J. RiederAPAlex P. ReinerBFBrian F. GageDADeborah A. NickersonCSCharles S. Eby

University of Washington · Seattle University · +1 more institution

PubMed
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Abstract

Background

The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin.

Methods

We conducted a retrospective study of European-American patients receiving long-term warfarin maintenance therapy. Multiple linear-regression analysis was used to determine the effect of VKORC1 haplotypes on the warfarin dose. We determined VKORC1 haplotype frequencies in African-American, European-American, and Asian-American populations and VKORC1 messenger RNA (mRNA) expression in human liver samples.

Citation impact

1,392
total citations
FWCI
125.66
Percentile
100%
References
20
Citations per year

Authors

10

Topics & keywords

Topics
Keywords
  • Haplotype
  • VKORC1
  • Vitamin K epoxide reductase
  • Warfarin
  • Single-nucleotide polymorphism
  • Internal medicine
  • Medicine
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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