Quantitative Analysis of Fission Yeast Transcriptomes and Proteomes in Proliferating and Quiescent Cells
University College London · University of Basel · +3 more institutions
Abstract
Data on absolute molecule numbers will empower the modeling, understanding, and comparison of cellular functions and biological systems. We quantified transcriptomes and proteomes in fission yeast during cellular proliferation and quiescence. This rich resource provides the first comprehensive reference for all RNA and most protein concentrations in a eukaryote under two key physiological conditions. The integrated data set supports quantitative biology and affords unique insights into cell regulation. Although mRNAs are typically expressed in a narrow range above 1 copy/cell, most long, noncoding RNAs, except for a distinct subset, are tightly repressed below 1 copy/cell. Cell-cycle-regulated transcription…
Citation impact
- FWCI
- 22.70
- Percentile
- 100%
- References
- 69
Authors
6Topics & keywords
- Biology
- Yeast
- Transcriptome
- Proteome
- Fission
- Cell biology
- Schizosaccharomyces
- Computational biology