Helicobacter pylori persistence: biology and disease

Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the ecology of the indigenous microbiota. A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia.

• UD
  U.S. Department of Veterans Affairs
• DD
  Doris Duke Charitable Foundation
• NI
  National Institutes of Health

  Awards: R01DK53707, R01GM63270
• MR
  Medical Research Council