Immuno Gold Nanocages with Tailored Optical Properties for Targeted Photothermal Destruction of Cancer Cells
University of Washington · Johns Hopkins University · +2 more institutions
Abstract
Gold nanocages with a relatively small size (e.g., approximately 45 nm in edge length) have been developed, and the structure of these nanocages was tailored to achieve strong absorption in the near-infrared (NIR) region for photothermal cancer treatment. Numerical calculations show that the nanocage has a large absorption cross section of 3.48 x 10(-14) m(2), facilitating conversion of NIR irradiation into heat. The gold nanocages were conjugated with monoclonal antibodies (anti-HER2) to target epidermal growth factor receptors (EGFR) that are overexpressed on the surface of breast cancer cells (SK-BR-3). Our preliminary photothermal results show that the nanocages strongly absorb light in the NIR region with…
Citation impact
- FWCI
- 36.21
- Percentile
- 100%
- References
- 20
Authors
10- JCJingyi ChenCorresponding
University of Washington, Johns Hopkins University, Institute of Physics, Chinese Academy of Sciences
- DWDanling Wang
Chinese Academy of Sciences, Institute of Physics, Johns Hopkins University, University of Washington
- JXJiefeng Xi
University of Washington, Institute of Physics, Chinese Academy of Sciences, Johns Hopkins University
- LALeslie Au
Chinese Academy of Sciences, Institute of Physics, University of Washington, Johns Hopkins University
- ASAndy Siekkinen
Chinese Academy of Sciences, University of Washington, Institute of Physics, Johns Hopkins University
Topics & keywords
- Nanocages
- Photothermal therapy
- Photothermal effect
- Materials science
- Irradiation
- Nanoshell
- Absorption (acoustics)
- Nanotechnology
- Good health and well-being