Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

Park, Dong‐Wook; Schendel, Amelia A.; Mikael, Solomon; Brodnick, Sarah K.; Richner, Thomas J.; Ness, Jared P.; Hayat, Mohammed; Atry, Farid; Frye, Seth; Pashaie, Ramin; Thongpang, Sanitta; Ma, Zhenqiang; Williams, Justin C.

doi:10.1038/ncomms6258

articleNature CommunicationsOct 20, 2014HYBRID OA

Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

DPDong‐Wook Park AAAmelia A. Schendel SMSolomon Mikael SKSarah K. Brodnick TJThomas J. Richner

University of Wisconsin–Madison · University of Wisconsin–Milwaukee · +1 more institution

PubMed

Indexed incrossrefdoajpubmed

Abstract

Neural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its…

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Keywords

Optogenetics
Materials science
Optical coherence tomography
Graphene
Electrode
Electrode array
Fluorescence-lifetime imaging microscopy
Nanotechnology

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