Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women
University of Washington · Perinatal HIV Research Unit · +14 more institutions
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Abstract
Background
Reproductive-age women need effective interventions to prevent the acquisition of human immunodeficiency virus type 1 (HIV-1) infection.
Methods
We conducted a randomized, placebo-controlled trial to assess daily treatment with oral tenofovir disoproxil fumarate (TDF), oral tenofovir-emtricitabine (TDF-FTC), or 1% tenofovir (TFV) vaginal gel as preexposure prophylaxis against HIV-1 infection in women in South Africa, Uganda, and Zimbabwe. HIV-1 testing was performed monthly, and plasma TFV levels were assessed quarterly.
Citation impact
1,304
total citations
- FWCI
- 111.56
- Percentile
- 100%
- References
- 19
Citations per year
Authors
26Topics & keywords
Topics
Keywords
- Medicine
- Hazard ratio
- Pre-exposure prophylaxis
- Emtricitabine
- Confidence interval
- Placebo
- Internal medicine
- Microbicide
UN Sustainable Development Goals
- Good health and well-being
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