The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
Ollscoil na Gaillimhe – University of Galway · Ludwig-Maximilians-Universität München · +3 more institutions
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695
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5Topics & keywords
Topics
Keywords
- Quinolinic acid
- Indoleamine 2,3-dioxygenase
- Kynurenine pathway
- Kynurenine
- Tryptophan
- Endocrinology
- Immune system
- Oxidative stress
UN Sustainable Development Goals
- Good health and well-being
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