Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria

Risk factors for grades 2-4 acute graft-versus-host disease (GVHD) and for chronic GVHD as defined by National Institutes of Health consensus criteria were evaluated and compared in 2941 recipients of first allogeneic hematopoietic cell transplantation at our center. In multivariate analyses, the profiles of risk factors for acute and chronic GVHD were similar, with some notable differences. Recipient human leukocyte antigen (HLA) mismatching and the use of unrelated donors had a greater effect on the risk of acute GVHD than on chronic GVHD, whereas the use of female donors for male recipients had a greater effect on the risk of chronic GVHD than on acute GVHD. Total body irradiation was strongly associated…

• UD
  U.S. Department of Defense
• UD
  U.S. Department of Health and Human Services

  Awards: CA15704, CA18029
• NI
  National Institutes of Health

  Awards: HL36444, CA18029, CA15704, HL36444, CA15704
• UN
  U.S. Navy
• OO
  Office of Naval Research

  Awards: N00014-06-1-0704, N00014