articleAmerican Journal of Physical AnthropologyApr 2, 2007Closed access

Collagen turnover in the adult femoral mid‐shaft: Modeled from anthropogenic radiocarbon tracer measurements

RHR.E.M. HedgesJGJohn G. ClementCDC. David L. ThomasTCTamsin C. O’Connell

University of Oxford · Oxford Archaeology · +2 more institutions

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Abstract

We have measured the (14)C content of human femoral mid-shaft collagen to determine the dynamics of adult collagen turnover, using the sudden doubling and subsequent slow relaxation of global atmospheric (14)C content due to nuclear bomb testing in the 1960s and 1970s as a tracer. (14)C measurements were made on bone collagen from 67 individuals of both sexes who died in Australia in 1990-1993, spanning a range of ages at death from 40 to 97, and these measurements were compared with values predicted by an age-dependent turnover model. We found that the dataset could constrain models of collagen turnover, with the following outcomes: 1) Collagen turnover rate of females decreases, on average, from 4%/yr to…

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Topics & keywords

Topics
Keywords
  • TRACER
  • Bone remodeling
  • Turnover
  • Protein turnover
  • Chemistry
  • Internal medicine
  • Endocrinology
  • Animal science
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