Causal interactions between fronto-parietal central executive and default-mode networks in humans

Information processing during human cognitive and emotional operations is thought to involve the dynamic interplay of several large-scale neural networks, including the fronto-parietal central executive network (CEN), cingulo-opercular salience network (SN), and the medial prefrontal-medial parietal default mode networks (DMN). It has been theorized that there is a causal neural mechanism by which the CEN/SN negatively regulate the DMN. Support for this idea has come from correlational neuroimaging studies; however, direct evidence for this neural mechanism is lacking. Here we undertook a direct test of this mechanism by combining transcranial magnetic stimulation (TMS) with functional MRI to causally excite…

• UD
  U.S. Department of Veterans Affairs
• WR
  War Related Illness and Injury Study Center
• NI
  National Institutes of Health

  Awards: P41 EB015891, EB015891
• NC
  NIH Clinical Center