A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound
Université Paris Cité · Inserm · +5 more institutions
Abstract
Bisphenol A (BPA) is a widely studied typical endocrine-disrupting chemical, and one of the major new issues is the safe replacement of this commonly used compound. Bisphenol S (BPS) and bisphenol F (BPF) are already or are planned to be used as BPA alternatives. With the use of a culture system that we developed (fetal testis assay [FeTA]), we previously showed that 10 nmol/L BPA reduces basal testosterone secretion of human fetal testis explants and that the susceptibility to BPA is at least 100-fold lower in rat and mouse fetal testes. Here, we show that addition of LH in the FeTA system considerably enhances BPA minimum effective concentration in mouse and human but not in rat fetal testes. Then, using the…
Citation impact
- FWCI
- 19.62
- Percentile
- 100%
- References
- 96
Authors
10- SESoria EladakCorresponding
Université Paris Cité, Inserm, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, CEA Paris-Saclay - Etablissement de Fontenay-aux-roses, Délégation Paris 7
- TGTiphany Grisin
Université Paris Cité, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Inserm, CEA Paris-Saclay - Etablissement de Fontenay-aux-roses, Délégation Paris 7
- DMDelphine Moison
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris Cité, Délégation Paris 7, Inserm
- MGMarie-Justine Guerquin
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses, Délégation Paris 7, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris Cité, Inserm
- TNThierry N’Tumba-Byn
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Délégation Paris 7, Inserm, Université Paris Cité
Topics & keywords
- Bisphenol A
- Bisphenol S
- Fetus
- Endocrinology
- Internal medicine
- Endocrine system
- Bisphenol
- Testosterone (patch)