The Population Genetics of dN/dS
University of Pennsylvania · Applied Mathematics (United States)
Abstract
Evolutionary pressures on proteins are often quantified by the ratio of substitution rates at non-synonymous and synonymous sites. The dN/dS ratio was originally developed for application to distantly diverged sequences, the differences among which represent substitutions that have fixed along independent lineages. Nevertheless, the dN/dS measure is often applied to sequences sampled from a single population, the differences among which represent segregating polymorphisms. Here, we study the expected dN/dS ratio for samples drawn from a single population under selection, and we find that in this context, dN/dS is relatively insensitive to the selection coefficient. Moreover, the hallmark signature of positive…
Citation impact
- FWCI
- 15.39
- Percentile
- 100%
- References
- 66
Authors
2Topics & keywords
- Biology
- Population
- Selection (genetic algorithm)
- Genetics
- Effective population size
- Negative selection
- Evolutionary biology
- Context (archaeology)