A Longitudinal Study of Brain Volume Changes in Normal Aging Using Serial Registered Magnetic Resonance Imaging
UK Dementia Research Institute · University College London · +4 more institutions
Abstract
To investigate the effect of age on global and regional brain volumes and rates of atrophy, and to compare directly results based on cross-sectional and longitudinal data.
Thirty-nine healthy control subjects (age range, 31-84 years) underwent serial magnetic resonance imaging assessments. Measurements included the whole-brain, temporal lobe, hippocampal, and ventricular volumes at baseline and for repeat scans.
We found significant decreases in cross-sectional whole-brain (P
Citation impact
- FWCI
- 10.95
- Percentile
- 100%
- References
- 41
Authors
6- RIRachael I. ScahillCorresponding
UK Dementia Research Institute, University College London
- CFChris Frost
London School of Hygiene & Tropical Medicine, University College London
- RJRhian Jenkins
UCL Australia
- JLJennifer L. Whitwell
UK Dementia Research Institute, University College London, London School of Hygiene & Tropical Medicine, Hologic (Germany)
- MNMartin N. Rossor
Imperial College London, University College London
Topics & keywords
- Atrophy
- Magnetic resonance imaging
- Brain size
- Temporal lobe
- Cardiology
- Medicine
- Lateral ventricles
- Brain aging
- Reduced inequalities