Neutrophils and Wound Repair: Positive Actions and Negative Reactions

SIGNIFICANCE: Neutrophils are one of the most abundant cells of the immune system and they are extremely active during the repair of cutaneous wounds. In general, the antimicrobial activity of neutrophils is effective and allows these cells to carry out their primary function of preventing wounds from becoming infected. RECENT ADVANCES: It is now known that in addition to sterilizing the wound, the weapons used by neutrophils to kill potential pathogens can also cause significant tissue damage to the host. This additional damage can lead to delayed healing and excessive scar formation. CRITICAL ISSUES: Much of the host damage caused by neutrophils results from the activity of proteases secreted by these cells.…

• OS
  Ohio State University

  Award: UL1RR025755
• NI
  National Institutes of Health

  Awards: UL1RR025755, CA127109, DK076566