GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes
University of Copenhagen · Novo Nordisk Foundation · +2 more institutions
Abstract
The expression of short-chain fatty acid receptors GPR41/FFAR3 and GPR43/ free fatty acid receptor 2 (FFAR2) was studied in the gastrointestinal tract of transgenic monomeric red fluorescent protein (mRFP) reporter mice. In the stomach free fatty acid receptor 3 (FFAR3)-mRFP was expressed in a subpopulation of ghrelin and gastrin cells. In contrast, strong expression of FFAR3-mRFP was observed in all cholecystokinin, glucose-dependent insulinotropic peptide (GIP), and secretin cells of the proximal small intestine and in all glucagon-like peptide-1 (GLP-1), peptide YY, and neurotensin cells of the distal small intestine. Throughout the colon and rectum, FFAR3-mRFP was strongly expressed in the large population…
Citation impact
- FWCI
- 19.37
- Percentile
- 100%
- References
- 51
Authors
13- MKMark K. Nøhr
University of Copenhagen, Novo Nordisk Foundation
- MHMaria H. Pedersen
University of Copenhagen, Novo Nordisk Foundation
- AGAndreas Gille
Max Planck Institute for Heart and Lung Research
- KLKristoffer L. Egerod
University of Copenhagen, Novo Nordisk Foundation
- MSMaja S. Engelstoft
University of Copenhagen, Novo Nordisk Foundation
Topics & keywords
- Enteroendocrine cell
- Internal medicine
- Endocrinology
- Enteric bacteria
- Short-chain fatty acid
- Biology
- Chemistry
- Medicine