Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis
University Medical Center · University of Kansas Medical Center · +2 more institutions
Abstract
Nucleotide sequences from a total of 421 HEV isolates were retrieved from Genbank and analysed. Phylogenetically, HEV was classified into four major genotypes. Genotype 1 was more conserved and classified into five subtypes. The number of genotype 2 sequences was limited but can be classified into two subtypes. Genotypes 3 and 4 were extremely diverse and can be subdivided into ten and seven subtypes. Geographically, genotype 1 was isolated from tropical and several subtropical countries in Asia and Africa, and genotype 2 was from Mexico, Nigeria, and Chad; whereas genotype 3 was identified almost worldwide including Asia, Europe, Oceania, North and South America. In contrast, genotype 4 was found exclusively…
Citation impact
- FWCI
- 13.73
- Percentile
- 100%
- References
- 129
Authors
3Topics & keywords
- Genotype
- Biology
- Phylogenetic tree
- Zoonosis
- GenBank
- Virology
- Genetic diversity
- Phylogenetics