Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival
National Cancer Institute · National Institutes of Health · +6 more institutions
Abstract
BACKGROUND: Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure. METHODOLOGY/PRINCIPAL FINDINGS: We performed gene expression analysis using HG-U133A Affymetrix chips on 135 fresh frozen tissue samples of adenocarcinoma and paired noninvolved lung tissue from current, former and never smokers, with biochemically validated smoking information. ANOVA analysis adjusted for potential confounders, multiple testing procedure, Gene Set Enrichment Analysis, and GO-functional classification were conducted for gene selection. Results were confirmed in independent…
Citation impact
- FWCI
- 18.07
- Percentile
- 100%
- References
- 33
Authors
19- MTMaria Teresa LandiCorresponding
National Cancer Institute, National Institutes of Health
- TDTatiana Dracheva
National Cancer Institute, National Institutes of Health, Center for Cancer Research
- MRMelissa Rotunno
National Institutes of Health, National Cancer Institute
- JDJonine D. Figueroa
National Cancer Institute, United States Department of Health and Human Services, National Institutes of Health
- HLHuaitian Liu
National Cancer Institute, National Institutes of Health
Topics & keywords
- Lung cancer
- Adenocarcinoma
- Carcinogenesis
- Gene signature
- Lung
- Immunohistochemistry
- Oncology
- Biology
- Good health and well-being