Near Infrared Laser-Induced Targeted Cancer Therapy Using Thermoresponsive Polymer Encapsulated Gold Nanorods
National Center for Nanoscience and Technology · Houston Methodist
Abstract
External stimuli, such as ultrasound, magnetic field, and light, can be applied to activate in vivo tumor targeting. Herein, we fabricated polymer encapsulated gold nanorods to couple the photothermal properties of gold nanorods and the thermo- and pH-responsive properties of polymers in a single nanocomposite. The activation mechamism was thus transformed from heat to near-infrared (NIR) laser, which can be more easily controlled. Doxorubicin, a clinical anticancer drug, can be loaded into the nanocomposite through electrostatic interactions with high loading content up to 24%. The nanocomposite's accumulation in tumor post systematic administration can be significantly enhanced by NIR laser irradiation,…
Citation impact
- FWCI
- 43.08
- Percentile
- 100%
- References
- 32
Authors
8- ZZZhenjiang ZhangCorresponding
National Center for Nanoscience and Technology
- JWJing Wang
National Center for Nanoscience and Technology
- XNXin Nie
National Center for Nanoscience and Technology
- TWTao Wen
National Center for Nanoscience and Technology
- YJYinglu Ji
National Center for Nanoscience and Technology
Topics & keywords
- Nanorod
- Photothermal therapy
- Nanocomposite
- Chemistry
- Laser
- Photothermal effect
- Doxorubicin
- Nanotechnology
- Good health and well-being