The selectivity of protein kinase inhibitors: a further update
University of Dundee · MRC Protein Phosphorylation and Ubiquitylation Unit
Abstract
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases. On the basis of this information, the effects of compounds that we have studied in cells and other data in the literature, we recommend the use of the following small-molecule inhibitors: SB 203580/SB202190 and BIRB 0796 to be used in parallel to assess the physiological roles of p38 MAPK (mitogen-activated protein kinase) isoforms, PI-103 and wortmannin to be used in parallel to inhibit phosphatidylinositol (phosphoinositide) 3-kinases, PP1 or PP2 to be used in parallel with Src-I1 (Src inhibitor-1) to inhibit Src family members; PD 184352 or PD…
Citation impact
- FWCI
- 68.39
- Percentile
- 100%
- References
- 94
Authors
10Topics & keywords
- Kinase
- Mitogen-activated protein kinase kinase
- ASK1
- Cyclin-dependent kinase 9
- MAP kinase kinase kinase
- Biology
- Cyclin-dependent kinase 2
- Protein kinase B