reviewMacromolecular BioscienceDec 27, 2010Closed access

Advances in Mucoadhesion and Mucoadhesive Polymers

VVVitaliy V. Khutoryanskiy

University of Reading

PubMed
Indexed incrossrefpubmed

Abstract

Mucoadhesion is the ability of materials to adhere to mucosal membranes in the human body and provide a temporary retention. This property has been widely used to develop polymeric dosage forms for buccal, oral, nasal, ocular and vaginal drug delivery. Excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups and/or non-ionic functional groups capable of forming hydrogen bonds with mucosal surfaces. This feature article considers recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview on the structure of mucosal membranes, properties of mucus gels and the nature of mucoadhesion. It describes the most common methods to evaluate…

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626
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FWCI
10.85
Percentile
100%
References
108
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • Mucoadhesion
  • Buccal administration
  • Drug delivery
  • Polymer
  • Mucus
  • Chemistry
  • Polymer chemistry
  • Materials science
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