articleJournal of Clinical InvestigationMay 6, 2008GREEN OA

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

JHJun Hyung ParkDADoris A. StoffersRDRobert D. NichollsRARebecca A. Simmons

University of Pennsylvania · Diabetes Australia · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Intrauterine growth retardation (IUGR) has been linked to the onset of diseases in adulthood, including type 2 diabetes, and has been proposed to result from altered gene regulation patterns due to epigenetic modifications of developmental genes. To determine whether epigenetic modifications may play a role in the development of adult diabetes following IUGR, we used a rodent model of IUGR that expresses lower levels of Pdx1, a pancreatic and duodenal homeobox 1 transcription factor critical for beta cell function and development, which develops diabetes in adulthood. We found that expression of Pdx1 was permanently reduced in IUGR beta cells and underwent epigenetic modifications throughout development. The…

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Topics & keywords

Topics
Keywords
  • PDX1
  • Epigenetics
  • Biology
  • Endocrinology
  • DNA methylation
  • Internal medicine
  • Histone
  • Epigenetic regulation of neurogenesis
UN Sustainable Development Goals
  • Good health and well-being
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