articleJournal of Biological ChemistryNov 5, 2011HYBRID OA

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

SSSudad SamanWKWonHee KimMRMario RayaYVYvonne VisnickSMSuhad Miro

University of Massachusetts Lowell · Massachusetts Bay Community College · +4 more institutions

Indexed incrossrefdoaj

Abstract

Background

Tau is secreted unconventionally, possibly explaining increased CSF phosphotau levels in early AD.

Results

M1C cells secrete selectively phosphorylated, exosomal tau. These characteristics in early AD CSF tau suggest that CSF tau is secreted, not shed from dead neurons.

Conclusion

Tau secretion occurs early and may explain lesion spreading in AD.

Significance

Secretion biomarkers may become revolutionary prospective AD diagnostics.

Citation impact

980
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25.27
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100%
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50
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Authors

11

Topics & keywords

Topics
Keywords
  • Tauopathy
  • Exosome
  • Neurodegeneration
  • Secretion
  • Microvesicles
  • Tau protein
  • Cerebrospinal fluid
  • Alzheimer's disease
UN Sustainable Development Goals
  • Good health and well-being
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